NIP45 negatively regulates RANK ligand induced osteoclast differentiation
نویسندگان
چکیده
منابع مشابه
MafB negatively regulates RANKL-mediated osteoclast differentiation.
Receptor activator of nuclear factor kappaB ligand (RANKL) induces osteoclast formation from hematopoietic cells via regulation of various transcription factors. Here, we show that MafB negatively regulates RANKL-induced osteoclast differentiation. Expression levels of MafB are significantly reduced by RANKL during osteoclastogenesis. Overexpression of MafB in bone marrow-derived monocyte/macro...
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A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation and activation has been identified via genomic analysis of a primary osteoclast precursor cell cDNA library and is identical to the tumor necrosis factor receptor (TNFR) family member RANK. The RANK mRNA was highly expressed by isolated bone marrow-derived osteoclast progenitors and by mature osteoclasts i...
متن کاملMafB negatively regulates RANKL-mediated osteoclast differentiation (Short title: The negative role of MafB in osteoclastogenesis)
To whom correspondence should be addressed: Nacksung Kim, Ph.D. Medical Research Center for Gene Regulation, Chonnam National University Medical School, Hak-Dong 5, Dong-Ku, Gwangju 501-746, Korea. Phone: 82-62-220-4418, Fax: 82-62-223-4018, E-mail: [email protected] Contribution K.Kim, J.H.Kim, J.Lee, and H.M.Jin : performed research and analyzed data H.Kook : contributed vital reagents K.K.K...
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Negative regulator of reactive oxygen species (NRROS) is known to repress ROS generation in phagocytes. In this study, we examined the roles of NRROS in both osteoclasts and osteoblasts. Our results demonstrate that NRROS negatively regulates the differentiation of osteoclasts, but not osteoblasts. Further, overexpression of NRROS in osteoclast precursor cells attenuates RANKL-induced osteoclas...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2012
ISSN: 0730-2312
DOI: 10.1002/jcb.23460